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Undetected or untreated excess iron kills after inflicting injury to a variety of body organs, e.g. liver (cancer), (heart) attack, (brain) stroke.

Excess iron lowers the immune system.  Many diseases will show a poor outcome unless any excess iron is removed:  AIDs, cancer and hepatitis, for example.

Excess iron stored in the brain has been found to exacerbate severity in Alzheimer's, MS, Lou Gehrig's, Parkinson's and other diseases.  Iron in the brain also leads to psychological problems. 

To prevent iron overload, one should aim for “% of Saturation” (also called Transferrin Saturation TS) within 12 – 44%, and “Iron in the Blood” (i.e. Serum Ferritin SI) within 5 – 150.