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Pregnant women exposed to Lamictal (lamotrigine) in the first trimester may give birth to infants with cleft lip and cleft palate. The rate is 1 in 100 births (compared to 0.03 per 100 in non-Lamictal population). To facilitate monitoring fetal outcomes of pregnant women exposed to lamotrigine, patients are encouraged to enroll in the North American Antiepileptic Drug (NAAED) Pregnancy Registry by calling (888) 233-2334.