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Taking MSM orally alone or in combination with glucosamine can modestly reduce some symptoms of osteoarthritis such as pain and swelling, and improve joint function or physical function.

MSM is a naturally occurring compound found in green plants, fruits and vegetables, grains, milk. MSM is a source of sulfur for the amino acids cysteine and methionine.

MSM is primarily used for osteoarthritis. Preliminary research suggests MSM might inhibit degenerative changes in joints in animal models of osteoarthritis.

MSM is also being studied for allergic rhinitis. 

Orally, MSM may cause nausea, diarrhea, bloating, headache, fatigue, insomnia, and difficulty concentrating.

For osteoarthritis, 500 mg three times daily up to 3 grams twice daily has been used.

For allergic rhinitis, 2600 mg per day has been used.