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While Gravol (dimenhydrinate) is safe and effective in controlling nausea and vomiting, some people have abused it in high doses for its euphoric and hallucinogenic effects, often in conjunction with other psychoactive substances and alcohol. Gravol in high doses can cause toxic effects: ataxia, toxic psychosis, excitement, seizures, hypotension, and cardiac arrhythmias. Fatalities have resulted from the ingestion of very high doses, especially when combined with alcohol or other substances of abuse. Psychiatric symptoms which may be produced by chronic abuse include thought disorders, difficulty in concentrating, amnesia, lethargy, psychosis, hallucination, and delirium.