DEPRESSANT EFFECTS OF OPIOIDS

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Opioid analgesics like oxycodone possess depressant activities like respiratory depression, blood pressure reduction, and sedation. Co-administration with other depressants such as alcohol, pain killers, anesthetics, sedatives, hypnotics, barbiturates, phenothiazines, chloral hydrate and glutethimide, MAO inhibitors (including procarbazine HCl), pyrazolidone antihistamines, beta-blockers, will only compound the problem. Respiratory depression, hypotension and profound sedation or coma may result