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Safety information has been added to Tegretol product monograph.

Serious and sometimes fatal dermatologic reactions, including Toxic Epidermal Necrolysis (TEN) and Stevens-Johnson Syndrome (SJS), have been reported with Tegretol. Occurrence happens more in Asian population (10x more) and may be due to presence of a gene HLA-B1502.

Anti-epileptic drugs have been known to cause the occasional skin reactions.

Tegretol is indicated for the treatment of epilepsy, as well as trigeminal neuralgia, mania, and bipolar disorders.

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