CAMPRAL (ACAMPROSATE) FOR ALCOHOL DEPENDENCE
Campral prevents relapse in patients who have quit drinking. Management of alcohol dependence is challenging because half of those will go back to drinking after 2 years abstinence.
Chronic exposure to alcohol results in dysregulation of neuronal excitation and inhibition which are mediated by glutamate and GABA. Campral act on these receptors to restore the normal balance between gluatmatergic excitation and GABAergic inhibition.
Campral tablets are enteric-coated. Each tablet contains 333mg acamprosate. There are 7 strips of 12 tablets each in a box.
Intial dosage is 1 tablet TID. Increase by 1 tablet a week until average dosage of 2 tablets TID is reached.
Campral is well tolerated. Most common side effects are nausea, upset stomach, and diarrhea. Drug interaction potentials are low.