WELLBUTRIN (BUPROPION) SEIZURE CONSIDERATIONS

WELLBUTRIN SEIZURE CONSIDER image healthtips images

Seizure occurrence is about 1 per 1000 in dose range of up to 300mg per day.

At 400mg dose per day, seizure occurrence increases to 4 per 1000.

Above 450mg daily dose, there is 10-fold increase in seizures.

 

Predisposing risk factors

 

·          History of prior seizure

·          History of head trauma

·          Central nervous system tumour

·          Severe hepatic impairment

·          Excessive use of alcohol; addiction to opiates, cocaine, or stimulants

·          Use of concomitant medications that lower seizure threshold: antipsychotics, andtidepressants, lithium, amantadine, steroids, quinolone antibiotics, anti-malarials

·          Use of OTC stimulants or anorectics

·          Diabetes treated with oral hypoglycemics or insulin

·          Current or prior diagnosis of bulimia or anorexia nervosa

·          Abrupt withdrawal from alcohol, benzodiazepines or other sedatives